Eddie Howe will be hoping his side continue where they left off in their previous league game against Sheffield Utd, although he will first have to check in with his medical team to see who he has available before making his team selection.
Alexander Isak limped off with what looked like a calf problem in the Magpies victory over Man City in midweek while Bruno Guimaraes and Paul Dummett both required the services of the physio during that game.
Callum Wilson and Sven Botman missed the fixture due to respective hamstring and knee issues picked up at Bramall Lane while Martin Dubravka and Dan Burn both missed out due to illness.
Harvey Barnes and Joe Willock are both ruled out while Emil Krafth continues his rehabilitation from the ACL injury suffered last season.
Howe does however have Joelinton back in the squad and available following a short absence with a knee problem.
Burnley head coach Vincent Kompany has his own injury worries with several key players likely to be unavailable. Summer signing Nathan Redmond is not expected to feature having missed the last three games through injury and he was joined on the treatment table this week by Marcus Benson.
Michael Obafemi, Hjalmar Ekdal and Darko Churlinov will also miss the trip through injury while Lyle Taylor misses out as he serves the third game of his three-game ban.
Speaking to the press ahead of the game Kompany said: “Newcastle is a big test if I’m honest. I’d always put it on the calendar as a big test.
“It’s difficult to predict because of the threats and the weapons they have, but there is something there for us in terms of having a good performance and hopefully a result as well”
“There are not many harder away grounds that are harder than that ground. I’m really interested in seeing where the team is against that level away from home. It’s something I’m looking forward to. If you play well at St James’, it’s not just about playing well, we want the result like every other game. It’s not arrogant to say that, why else are you in the Premier League?
“But a performance at St James’ Park should give you the feeling that you can perform everywhere in this league. That’s what you’re in the game for. For every tough opponent, every team of that calibre, there is a small opportunity to do something special and that you’ll be remembered for."
The referee for this game is Thomas Bramall, and his assistants are Simon Bennett and Dan Robathan. Fourth official is Matt Donohue and the two people with the unenviable task of deciding what is or isn’t a handball, an offside or whether a player is “active” or not are Jarred Gillett and Scott Ledger as they occupy the VAR ejector hot seat.